Mark Corson

By D. Jaffar. Michigan State University. 2018.

Daniela Kniepeiss generic prednisolone 20 mg mastercard allergy forecast odessa tx, Helmut Mueller buy generic prednisolone 20mg on-line allergy testing tacoma, Kim buy 20mg prednisolone fast delivery allergy grocer, Gi-Won Song , Shin Hwang , Ki-Hun Kim , Chul-Soo Ahn. Department of Surgery, Division of Department of Surgery, Asan Medical Center, Seoul, Korea; 2Department of Radiology and Research Institute of Radiology, Transplantation, Medical University Graz, Graz, Austria Thanks to innovative surgical techniques, portal venous thrombosis no longer Asan Medical Center, Seoul, Korea is a contraindication for liver transplantation. It may be both fatal or benign self- described as a salvage technique but experience is still limited and there is limiting. The purpose of this study is to elucidate the actual incidence of a high risk of serious complications. Matteo Donataccio, Giorgio Dalle Ore, divided into two groups : the recovery group and the mortality group. The time interval varied very We previously published the feasibility of liver transplantation through only widely (7days∼7years). The mortality group shows with at last 3 months follow-up incisional hernia occurred in 5 out of 72 portomesenteric air-embolism, visceral infacrtion , and hemorrhagic ascites, subcostal incision (6,9%) and in 6 out of 29 others incisions (22. Orsola-Malpighi Hospital-University of numbness below the bilateral sub costal incision, above the umbilicus has Bologna, Bologna, Italy not been described. Haran Fisher, Vadim Shatz, Ernesto and Transplantation Surgery, Dzieciatka Jezus Clinical Hospital, Pretto. Aim: The course of Wilson’s liver disease can be highly variable ranging Her first Liver transplant in 1999 was due to auto-immune hepatitis. Hospital in Warsaw) in years 2000-2008 fourteen were carried out due to the Total operative time was 9 hours; during the procedure Splenectomy was fulminant Wilson’s disease. In two cases prothrombin Close co-operation with the blood bank as compatible blood may be difficult time was indeterminate. Anesthesia, Royal Free Hospital, London, United Choice of anti-rejection medication i. It may be an acute finding with full recovery of renal First, both patients may have suffered from a severe inflammation reaction function or may ultimately result in long-standing disease. However, few studies have addressed potential intraoperative but may be even measured in an anhepatic situation. Methods A cohort of 149 patients who received cadaveric liver transplant between Abstract# P-179 January 2006 and December 2007 were included in this retrospective study. Acute kidney injury, mortality, length of stay, and costs dimensions of the both A-P liver margins, A-P skin margins, portal triad, in hospitalized patients. Risk factors for renal dysfunction in the postoperative Results: Mean (cm) +/-Standard deviation (cm) course of liver transplant. Falk Rauchfuß1, Martin The data reveal a large interindividual variability in the liver dimensions Brauer2, Erik Bärthel1, Michael Heise1, Utz Settmacher1. We expected that this would result in sicker patients having transplant and ultimately have an effect on clinical bleeding and coagulopathy during surgery. Cryoprecipitate (Cryo) and Platelet (Plt) transfused were evaluated in both University of Barcelona, Barcelona, Spain;2Department of Surgery, groups. Bibiana decrease of both ventricular works; the most severe reduction was for left 1 1 1 1 ventricle (p≤0,001). Afterwards, we found a progressive ventricular function Escobar , Pilar Taura , Joan Beltran , Jaume Balust , Graciela recovering to normal values (Table 1). Alcoholic etiology may aggravate cardiovascular changes (g/min/m2) induced by cirrhosis. Two hours later, the arterial graft and Critical Care Therapy, Friedrich-Schiller University, Jena, Germany; Department of General, Visceral and Vascular Surgery,2 gave way and massive bleeding ensued. Aggressive resuscitation was done and acid Friedrich-Schiller University, Jena, Germany base and coagulation abnormalities corrected. The patient received 30 liters Introduction: of fluids intraoperatively including blood products and was extubated in the Acute or acute-on-chronic liver failure carries a high mortality. Vascular Surgery, Friedrich-Schiller-University, Jena, Germany; Discussion: 2Department for Anaesthesiology and Critical Care Medicine, Liver support systems are aimed to recover endogenous liver function or gain Friedrich-Schiller-University, Jena, Germany time until liver transplantation is available. Moreover, we quantified the dye excretion in the bile fluid 60, 120 and 180 minutes after dye injection. Recently some evidence emerged that subnormothermic temperatures Thy-1 immuno-staining was abundantly present in stromal cells and nerve might be a third way. Moreover an artificial haemoglobin Conclusions:While proliferation of mature cholangiocytes may be sufficient based oxygen carrier (Oxyglobin®) was used for providing sufficient oxygen to restore epithelial lining after mild injury, recruitment of cells from the under low flow conditions. Methods: Livers from non-heparinized Lewis rats (250-270g) were harvested In this context, the peribiliary glands should be considered as a potential niche 60 min after cardiac death induced by phrenotomy. Finally livers were transplanted orthotopically using male Lewis rats as recipients (n≥5 for each group). Amine Zaouali , Ismail Ben Mosbah , Hassen Oxygen Ben Abdennebi2, Olivier Boillot3, Joan Rosello-Catafau1,4, Carmen consumption 2,45 ±0,56 1,65±0,90 182±62 n. Toshiaki Nakano1,2, (lipid peroxidation), revealed increased early injury in obese rats after I/R. Xiao anti-histone H1 autoreactive antibody (auto-Ab) induced in experimental Xu, Qi Ling, Feng Gao, Hai-Yang Xie, Shu-Sen Zheng. Division and clinical liver allograft tolerance (Transplantation 2004; 77: 1595 of Hepatobiliary and Pancreatic Surgery,Department of Surgery, and Transplantation 2007; 83: 1122). Ab, rabbit polyclonal Ab against histone H1 was intraperitoneally injected According to the different regimens given in the first two posttransplant immediately after ConA injection. In this autoimmune hepatitis model, anti-histone H1 auto-Ab was the first two post-transplant weeks, there was no significant difference in total transiently induced in the sera during the natural recovery stage at 3 to 7 days bilirubin, alanine transaminase, aspartate transaminase, serum creatinine, after ConA injection. There was no ConA-induced liver injury by inhibiting activation of effector T cells. Keywords: Diammonium Glycyrrhizinate; Kuhuang; Matrine; Liver Transplantation; Prognosis.

Effect of clopidogrel on platelet aggregation and plasma concentration of fibrinogen in subjects with cerebral or coronary atherosclerotic disease prednisolone 5 mg lowest price allergy virus symptoms. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease buy 10mg prednisolone visa allergy testing uk holland and barrett. A low molecular weight heparin buy prednisolone 40mg otc allergy medicine koger, nadroparin inhibits thrombin-induced platelet shape change and does not enhance spontaneous platelet aggregation. Increased platelet purinergic sensitivity in peripheral arterial disease--a pilot study. Platelets as predictors of vascular risk: is there a practical index of platelet activity? The effect of a loading dose of clopidogrel on platelet function in patients with peripheral arterial disease. Is aspirin still the anti- platelet drug of choice for patients with peripheral arterial disease? Correlations between platelet aggregation, fibrinolysis, peripheral and central serotonergic measures in subhuman primates. Naftidrofuryl inhibits the release of 5- hydroxytryptamine and platelet-derived growth factor from human platelets. Effect of milrinone in human platelet shape change, aggregation and thromboxane A2 synthesis: an in vivo study. The effect of clopidogrel, aspirin and both anti-platelet drugs on platelet function in patients with peripheral arterial disease. The effect of a loading dose of clopidogrel on platelet function in patients with peripheral arterial disease. The effect of tirofiban on fibrinogen/agonist-induced platelet shape change and aggregation. Related to chapter 1 *These publications (except for reference 5) overlap with the list of publications relating to platelet shape change and/or platelet aggregation, above. Intra-individual variability of residual platelet reactivity assessed by the VerifyNow-P2Y12 assay in patients with clopidogrel resistance after percutaneous coronary intervention. Assessment of platelet activation in several different anti- coagulants by the Advia 120 Hematology System, fluorescence flow cytometry, and electron microscopy. Effects of aspirin, dipyridamole, nifedipine and cavinton which act on platelet aggregation induced by different aggregating agents alone and in combination. Naftidrofuryl inhibits the release of 5- hydroxytryptamine and platelet-derived growth factor from human platelets. Measurement of platelet volume using a channelyzer: assessment of the effect of agonists and antagonists. Effect of naftidrofuryl and aspirin on platelet aggregation in peripheral vascular disease. Diminished platelet yield and enhanced platelet aggregability in platelet-rich plasma of peripheral vascular disease patients. The phospholipid composition and cholesterol content of platelet-derived microparticles: a comparison with platelet membrane fractions. Low density lipoprotein causes general cellular 229 activation with increased phosphatidylinositol turnover and lipoprotein catabolism. Meta-analysis of the efficacy and safety of clopidogrel plus aspirin as compared to anti-platelet monotherapy for the prevention of vascular events. Organization of the cytoskeleton in resting, discoid platelets: preservation of actin filaments by a modified fixation that prevents osmium damage. The effects of plasma lipoproteins on platelet responsiveness and on platelet and vascular prostanoid synthesis. Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis. Smoking and smoking cessation, the relationship between cardiovascular disease and lipoprotein metabolism. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Platelet hyperreactivity in hyperlipidaemia with specific reference to platelet lipids and fatty acid composition. A comparison of cilostazol and pentoxifylline for treating intermittent claudication. Failure of pentoxifylline or cilostazol to improve blood and plasma viscosity, fibrinogen, and erythrocyte deformability in claudication. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. Anti-thrombotic therapy in patients with coronary artery disease and with type 2 diabetes mellitus. Prasugrel as anti-platelet therapy in patients with acute coronary syndromes or undergoing percutaneous coronary intervention. The fine-tuning of anti-oxidized low-density lipoprotein anti-bodies in cardiovascular disease and thrombosis. Estimation of the concentration of low- density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Platelet aggregation: the use of optical density fluctuations to study microaggregate formation in platelet suspension. The platelet P2 receptors as molecular targets for old and new anti-platelet drugs. Distinct cholesterol and phospholipid incorporation at the platelet plasma membrane of hyperlipidemic subjects: structural order and function.

The drug is chiefly Production: Wild Yam root is the root and rhizome of used as a substitute for olive oil and in the manufacture of Dioscorea villosa cheap prednisolone 5 mg on-line allergy testing techniques. The root of the plant is used as a precursor for Handbuch der Pharmazeutischen Praxis buy 5mg prednisolone mastercard allergy infection, 5 generic prednisolone 40 mg overnight delivery allergy forecast edison nj. Though the (Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992- diosgenin componant has been promoted as a "natural 1994. The body does not convert diosgenin into H, Sakagami Y, Tsujibo H, Biological activity of purpurogallin. Anti-Inflammatory Effect: In the rat model, diosgenin has been found to decrease the intestinal inflammation that accompanies indomethacin use Wild Yam (Yamada et al, 1997). Diosgenin also has a cytoprotective effect on the rat (available from numerous manufacturers and as a combina- liver that is subjected to obstructive cholestasis (Accatino et tion product) al, 1998). Ovariectomized mice that Flower and Fruit: The plant has small greenish-yellow received diosgenin (sc) at dosage levels between 20 and 40 flowers. The male flowers are in drooping panicles; the mg/kg for 15 days had significant increases in mammary female ones in drooping spicate racemes. When administered estrogen and diosgenin, an augmentation of the estrogenic effect was Leaves, Stem and Root: Dioscorea villosa is a perennial vine. The leaves are broadly ovate, usually alternating, Unproven Uses: Wild Yam is used for rheumatic conditions, cordate and 6 to 14 cm long. They are alternate or opposite General: Health risks or side effects following the proper and in whorls of 3, which are flat or occasionally with a administration of designated therapeutic dosages are not turned-back border. Habitat: The plant is found all over Europe, Asia, Africa and Drug Interactions: There is evidence that the diosgenin America. Wild Yam may have an additive estrogenic herb is dried in the open air in the shade. Steroids: in particular beta-sitosterol Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3, Tannins Nachdruck, Georg Olms Verlag Hildesheim 1979. A watery infusion revealed a significant There are 4 sepals that are often colored and 8 stamens. A linear capsule-like, quadrangular, 4-valved and opens with 4 suspension of the fresh drug in ethanol stunts the growth of bending valves. Tincture and the may be covered in tiny warts with a white, often short- liquid extract showed anti-microbial effect against Candida stemmed, tuft of hair. There are 5 paper, shows a weak effect against Bacillus subtilis, Esche- stamens and 1 superior ovary. The fruit is a cherry-sized, richia coli, Mycobacterium smegmatis, Shigella flexneri, globular, scarlet berry, enclosed in the swollen, orange-red Shigella sonnei and Staphylococcus aureus. The drug was helpful in treating benign prostate angular with opposite, long-petioled, entire-margined leaves. Native Americans use the drug Production: Winter Cherry fruits are the ripe fruits of for rectal bleeding; the Chinese use it for menstrual Physalis alkekengi. Unproven Uses: Winter Cherry is used as a diuretic in Hansel R, Keller K, Rimpler H, Schneider G (Hrsg. The ripe fruit is edible, but unripe fruit can cause poisoning Hiemann A, Mayr K, Sci Pharm 53:39. Medicinal Parts: The medicinal parts are the ripe fruit and Kawai M, Matsuura T, (1970) Tetrahedron 26:1743. Biogene Gifte - Biologie, Chemie, Sesquiterpenes: including drimenol, drimenin, confertifoline, Pharmakologie. Medicinal Parts: The medicinal part is the dried bark of the trunk and larger branches. The sepals are membranous, broadly ovate to Handbuch der Pharmazeutischen Praxis, 5. The 4 to 14 petals are also membranous, oblong to (Drogen): Springer Verlag Berlin. There are 9 to 18 Hegnauer R, Chemotaxonomie der Pflanzen, Bde 1-11, ovules on a short seed stalk. The fruit is berry-like, black to Birkhauser Verlag Basel, Boston, Berlin 1962-1997. The leaf blade is coriaceous, oblong- ovate to elliptical, with a somewhat re volute margin. The bark is collected from the dried trunk or flowers grow from the base of the leaves. They are fleshy, globular, bilocular, and contain Not to be Confused With: The drug is often confused with numerous whitish, ovoid, flattened seeds. Cortex Canellae albae and with the bark of Cinnamodendron Leaves, Stem and Root: Gaultheria procumbens is a bushy corticosum. The active ingredient, methyl salicylate, is produced synthetically at a lower cost. Methyl Characteristics: Wintergreen has an aromatic odor; the taste salicylate is a constituent of liniments and bath additives. Monotropitoside (Gaultherin): changing into methyl salicy- late when the plant is dried Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3, Nachdruck, Georg Olms Verlag Hildesheim 1979. Daunderer M, Kormann K, Giftpflanzen, Pflanzengifte, Volatile oil: chief component methyl salicylate (96-98%), in 4. Health risks or side effects following the proper administra- tion of designated therapeutic dosages are not recorded. The Flower and Fruit: The androgynous and unisexual flowers drug and its volatile oil can, however, trigger contact grow in light to golden yellow, short-stemmed clusters on allergies.

Spinal Cord Injury in Patients with Infectious Spondyli- At lumbar and thoracic regions cheap 10 mg prednisolone free shipping allergy testing austin tx, vascular structures surrounding dural sac were prominent in contrast images order prednisolone 20mg mastercard allergy forecast victoria bc. Control angiography didn’t show any fnding of sion caused by infectious spondylitis purchase 5 mg prednisolone otc allergy shots make me tired. He had minimal hypoesthesia in the L5, S1 dermatomes Results: The mean age was 50 years (23-79). Maximal The resultant venous hypertension decreases spinal cord perfusion detrusor pressure was 54. Maximal cystometric 2 and can lead to ischemia and edema, resulting in slowly progres- capacity was 312. Detrusor sphincter dysyner- 2 sive myelopathy, sensory disturbances, and bowel and bladder gia was observed in 56% of cases. Six patients are treated by anticholinergic cases of this vascular malformation have been reported in the lit- medications and intermittent catheterization. Conclusion: condition that should be considered in the differential diagnosis of Urodynamic evaluation is an important test before treatment. In appropriate cases, emboliza- longer follow-up will determine if different therapeutic regimens tion treatment may be considered. Case Diagnosis: We present a case report on an alien hand syn- Branco drome in a stroke patient. Initial neurological examination demonstrated hypoes- to our hospital 8 months after he suffered a cardiac arrest and thesia of the left limbs but did not reveal any motor defcits. The patient was then admitted to the hospital for adequate by delirium, pancerebellar syndrome and myoclonus. The diagnosis of alien dysmetria, myoclonus of the upper extremities with movements, hand syndrome was considered. Occupational therapy was provided to the patient, in were increased but symmetrical. Discussion: Alien Hand with no changes on encephalic parenchyma, namely on basal gan- syndrome is a rare motor function disturbance that occurs follow- glia. Discussion: Cardiac arrest is the most common cause of involvement, commonly in the form of impaired consciousness. Material and Methods: A very sensitive Purkinje cell loss could contribute to neurologic 60-year-old female patient, with previous history of depression dysfunction, including posthypoxic myoclonus and ataxia. To the and hypertension, who developed, a neurological state of de- best of our knowledge, there have not been any reports concerning creased consciousness, ataxic gait, ophtalmoplegia and arrefexic cardiac arrest due to heat stroke. Heat stroke is characterized by faccid tetraparesis, days after an abdominal surgery for abscess hyperpyrexia, hot dry skin and central nervous system disturbance. The association of cardiac arrest and heat stroke with intravenous immunoglobulins, and improved consciousness is not described in the literature. It was only 16 weeks after the onset of cannot be fully cured, their functionality and quality of life can be symptoms, that she was admitted to a rehabilitation center. Kim4 mechanism, often triggered by previous infection, is the proposed 1National Rehabilitation Center, Seoul, 2Hanyang University, cause. Treatment comprises intravenous immunoglobulins and/or Seoul, 3Dankook University, Yong-in, 4National Rehabilitation plasmapheresis. Early, inten- sive, multimodal rehabilitation is determinant for the fnal func- Introduction/Background: Upper extremity functional defcits af- tional outcomes. Early referral for rehabilita- tried for upper extremity rehabilitation, however, hand rehabilita- tion is ideal, but it depends on a speedy diagnostic process. The change of those variables were compared between cial nerve, and leads to facial palsy, otalgia, and skin lesions of the the two groups using the linear mixed model. In addition, symptoms such as glove group showed the improvement of writing of Jebsen-Taylor dizziness and hearing loss may develop following involvement of hand function test (p=0. Changes of the Fugl-Meyer describing simultaneous involvement of the glossopharyngeal and assessment and other measurements did not differ between two vagus nerves. Material and glove system is a feasible rehabilitation tool for enhancing upper Methods: A 63-yr-old male patient, with a past medical history extremity, especially hand function in patients with stroke. Detailed physical examination revealed erythe- A Rare Mix for Rehabilitation: Bickerstaff Syndrome matous vesicles on the left auricle, gag refex was hyporefexic, Overlapped by Miller-Fisher Syndrome and Guillain- and laryngeal elevation was decreased when swallowing saliva. Acyclovir (800 mg/day) was administered intravenously for 1Centro Hospitalar de São João, Porto, 2Centro de Medicina de 21 days, and prednisolone (22. The characteristics of a lesion, licluding its volume, otalgia, hoarseness, and dizziness developed along with dyspha- have been suggested to infuence stroke recovery, but equivocal gia. Although the mechanism about descending involvement of evidence supports this precept. We To evaluate the relationship lower cranial nerves is uncertain, several hypotheses have been between volume of middle cerebral artery ischemic lesion and proposed. First, invasion of cranial nerves may have been due to postural control ability in the chronic phase of stroke. Patient who had hemorrhagic nerves are supplied by the ascending pharyngeal artery. The facial, or multiple stroke lesions, any neurologic condition(beyond the maxillary and mandibular nerves of the trigeminal nerve are sup- stroke) that impaired function of affected leg, previous history of plied by the middle meningeal artery. Lesion volume was obtained from of polyneuropathy occurring after vasculitis due to viral infection. A)) to determine the effect of computer-based The Relationship between Motivation and Functional work on postural balance. Static balance control was measured by equilibrium score and dynamic balance control was measured by Outcome in an Inpatient Rehabilitation Setting rhythmic weight shift test. Results: Data were collected 1 1 1 related to patient`s lesion volume (mean volume=14 cm3 or 4.

It is time that these psychiatrists took notice and listened to what patients and medical scientists keep telling them discount prednisolone 5mg on line allergy forecast pleasanton ca. How can symptoms that clearly indicate significant pathology be so persistently dismissed and sufferers be so denigrated buy 10 mg prednisolone amex allergy shots key west, given the nature and severity of the problems presented? These include not only the watered‐ down subjective description of “fatigue” buy generic prednisolone 40mg line allergy testing how many needles, but symptoms of organic pathology that ought to be unmissable by any doctor. Following publication of that report (which was internationally condemned for its extreme psychiatric bias and of which Professor Simon Wessely was understood to be the prime mover), the Editor of the Lancet, Richard Horton, courageously spoke out against it: “The college representatives interpreted every piece of evidence pointing to a biological cause in a negative light. Articles in “Clinical Evidence Concise” purport to summarise current knowledge about a disorder and are used in “best practice” guidelines. We cannot always rail at doctors when this is the information that they are receiving in mainstream, peer‐ reviewed medical journals”. Furthermore, pragmatic rehabilitation had no statistically significant effect on physical functioning; equally, its effect on depression had diminished at follow‐up. Notwithstanding, the investigators are already seeking further funding to test their hypothesis that providing more sessions might improve the effectiveness of pragmatic rehabilitation which they state “will inform the next phase of our work…. Is this another illustration of the Wessely School’s determination not be deterred by evidence that does not suit their own “evidence‐based” agenda? It’s a case of what the poet William Empson called ‘incessant belief labouring to create its object’. Illustrations of flawed methodology include the following: (1) The prime methodological flaw is the use of the all‐embracing Oxford entry criteria, which has been addressed above; essentially, the Principal Investigators have used entry criteria that do not define the population they purport to be studying. It should never be suggested to trial participants that the intervention they are undertaking is a cure unless it is certain that it is indeed curative, in which case there would be no need for a clinical trial to prove the efficacy of the intervention. To mislead patients by suggesting that a cure can be expected when there is no such certainty is in breach of the General Medical Council Regulations as set out in “Good Medical Practice” (2006): “Providing and publishing information about your services – paragraphs 60‐62 62. If you publish information about your medical services, you must make sure the information is factual and verifiable. You must not make unjustifiable claims about the quality or outcomes of your services in any information you provide to patients. It must not offer guarantees of cures, nor exploit patients’ vulnerability or lack of medical knowledge”. The Disability Handbook (2nd edition, 1998) is being revised chapter by chapter, and Chapter 16 (“The Chronic Fatigue Syndrome”) of May 2007 states: “There is no cure” (16: Management: 16). Up to December 2005 (when the changes took place), the Investigators had excluded 65 people from 140 applicants. Julia De Cesare to re‐word the Medical Screening Standard Operating Procedure according to Professor White’s recommendations”. The Trial Steering Committee and Ethics Committee apparently had no problem in agreeing to this further dilution of the trial cohort even though the trial was underway. Deliberately to include those with known psychiatric disorder in a trial that purports to be studying those with a classified neurological disorder undermines the rules of scientific inquiry. This can only mean that, because the entry criteria had been diluted, people in the second tranche were less ill. Such activity, whether physical or mental, has a characteristically delayed impact, which may be felt later the same day, the next day, or even later…In some instances the person can sustain a level of activity for several weeks, but a cumulative impact is seen, with a setback after several weeks or more”. Moreover, the Chief Investigator himself, Peter White, has published evidence supporting the need for serial post‐exercise testing ‐‐ see “Immunological changes after both exercise and activity in chronic fatigue syndrome: a pilot study”. Therefore, after spending millions of pounds of public money and involving hundreds of people in an intensive regime, they completely fail to obtain objective measurements that would reveal whether or not the interventions are successful. Physical activity in chronic fatigue syndrome: assessment and its role in fatigue. The authorsʹ reason for the study was because: ʺIt is not clear whether subjective accounts of physical activity level adequately reflect the actual level of physical activity…. The authors evaluated the correlations on seven outcome measures in relation to the actometer readings and demonstrated that “none of the self‐report questionnaires had strong correlations with the Actometer”. Having evaluated whether physical activity level can be adequately assessed by self‐report measures, the authors found that “self‐report questionnaires are no perfect parallel tests for the Actometer” and that subjective questionnaires “do not measure actual behaviour” because “responses may be biased by cognitions concerning illness and disability”. The authors continued: “In earlier studies of our research group, actual motor activity has been recorded with an ankle‐worn motion‐sensing device (actometer) in conjunction with self‐report measures of physical activity. The data of these studies suggest that self‐report measures of activity reflect the patientsʹ view about their physical activity and may have been biased by cognitions”. There is thus evidence that alleged improvements reported in subjective questionnaires may not be reliable. In clinical trials, there is an ethical requirement for equipoise, defined as “the point where there is no preference between treatments, i. The Trial Protocol cites Lilford et al and moreover it states: “those recruiting and randomising participants will rigorously maintain a position of equipoise and employ explanations that are consistent with this. All the participating clinicians regard all four treatments as potentially effective”. Lilford et al are clear: “Members of ethics committees should proceed on the basis that the question to be investigated has not already been answered. In some cases…the ‘experts’ (however defined) may all be in agreement as to which treatment is best. Lilford et al further state: “…the public might become suspicious and resentful if clinicians fail to disclose personal preferences in the interest of…convincing other clinicians”. For this reason, physicians who feel they already know the answer cannot enter their patients into a trial. That advertisement stated: “You will receive several months training prior to treating patients in the trial…. Indeed, Peter White actually included “Doctors” as a problem in his power point slides of his presentation at Bergen on 20th October 2009 in slide 37 in “Treatment issues” (http://www. That such a letter was deemed necessary demonstrates the very real and damaging effects of the Wessely School myth, for example, loss of benefits, loss of income protection and the consequent financial hardship that must be borne in addition to the burden imposed by the severity of the illness itself.